Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients

• Published in: Antimicrobial agents and chemotherapy Vol. 62; no. 7; pp. e00395 - 18
• Main Authors: Coolen-Allou, Nathalie, Touron, Thomas, Belmonte, Olivier, Gazaille, Virgile, Andre, Michel, Allyn, Jérôme, Picot, Sandrine, Payet, Annabelle, Veziris, Nicolas
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.07.2018
• Subjects: Amikacin; Anti-Bacterial Agents; Clarithromycin; Clinical Therapeutics; Fluoroquinolones; Human health and pathology; Infectious diseases; Life Sciences; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Pulmonology and respiratory tract; Santé publique et épidémiologie; lung; nontuberculous mycobacteria; Mycobacterium simiae; respiratory
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00395-18

is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least 1 sample positive for In our cohort, 97 patients (15.1%) were positive for Twenty-one patients (21.6%) met the American Thoracic Society (ATS) criteria for infection. infection was associated with bronchiectasis, micronodular lesions, and weight loss. Antibiotic susceptibility testing was performed for 60 patients, and the isolates were found to have low susceptibility to antibiotics, except for amikacin, fluoroquinolones, and clarithromycin. Treatment failed for 4 of the 8 patients treated for infection. Here, we describe a specific cluster corresponding to a large cohort of patients with , a rare nontuberculous mycobacterium associated with low pathogenicity and poor susceptibility to antibiotics.