Inhibition of Plasmodium Liver Infection by Ivermectin

Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite...

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Published inAntimicrobial agents and chemotherapy Vol. 61; no. 2
Main Authors Mendes, António M, Albuquerque, Inês S, Machado, Marta, Pissarra, Joana, Meireles, Patrícia, Prudêncio, Miguel
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.02.2017
Subjects
Animals
Cell Line, Tumor
Culicidae
Experimental Therapeutics
Humans
Ivermectin
Ivermectin - analogs & derivatives
Ivermectin - therapeutic use
Liver
Liver - parasitology
Malaria
Malaria - drug therapy
Plasmodium
Plasmodium - drug effects
Plasmodium - pathogenicity
Plasmodium
avermectins
liver stage
malaria
ivermectin
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Summary:Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage parasitemia, reducing disease severity and enhancing host survival. Ivermectin has been proposed as a tool to control malaria transmission because of its effects on the mosquito vector. Our study extends the effect of ivermectin to the early stages of mammalian host infection and supports the inclusion of this multipurpose drug in malaria control strategies.
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Present address: Joana Pissarra, UMR INTERTRYP, IRD, Montpellier, France.
Citation Mendes AM, Albuquerque IS, Machado M, Pissarra J, Meireles P, Prudêncio M. 2017. Inhibition of Plasmodium liver infection by ivermectin. Antimicrob Agents Chemother 61:e02005-16. https://doi.org/10.1128/AAC.02005-16.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.02005-16