Multistep Conformation Selection in Amyloid Assembly

Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 139; no. 47; pp. 17007 - 17010
Main Authors Hsieh, Ming-Chien, Liang, Chen, Mehta, Anil K, Lynn, David G, Grover, Martha A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 29.11.2017
Subjects
amyloid
Communication
therapeutics
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Summary:Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection.
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ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.7b09362