Selective Intermittent Preventive Treatment of Vivax Malaria: Reduction of Malaria Incidence in an Open Cohort Study in Brazilian Amazon

In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been i...

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Published inMalaria Research and Treatment Vol. 2013; no. 2013; pp. 38 - 48
Main Authors Silva, Josiane Mendes da, Rodrigues, Aline de Freitas, Tada, Mauro Shugiro, Fontes, Cor Jesus Fernandes, Pereira da Silva, Luiz Hildebrando, Katsuragawa, Tony Hiroshi, Santos Júnior, Alcides Procópio Justiniano dos, Nascimento Filha, Maria Teixeira do, Santos, Tatiana Marcondes dos, Gil, Luiz Herman Soares, Lima, Alzemar Alves de, Freitag, Elci Marlei
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 2013
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Cohort analysis
Control
Drug dosages
Ethics
Infections
Malaria
Medicine, Preventive
Patients
Prevention
Preventive health services
Surveillance
Brazil
Papua New Guinea
Madeira
Africa
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Summary:In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.
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Academic Editor: Mats Wahlgren
ISSN:2044-4362
2090-8075
2044-4362
DOI:10.1155/2013/310246