LIPOPROTEIN RECEPTORS IN THE NERVOUS SYSTEM

• Published in: Annual review of biochemistry Vol. 71; no. 1; pp. 405 - 434
• Main Authors: Herz, Joachim, Bock, Hans H
• Format: Journal Article
• Language: English
• Published: Palo Alto, CA 94303-0139 Annual Reviews 01.01.2002; 4139 El Camino Way, P.O. Box 10139 Annual Reviews, Inc; USA
• Subjects: Animals; apolipoprotein E; Apolipoproteins; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Brain - growth & development; Brain - physiology; Cardiovascular disease; Caveolae - metabolism; Cell Adhesion Molecules, Neuronal - metabolism; Central Nervous System - physiology; Cholesterol; Cholesterol - metabolism; Epidermal growth factor; Extracellular Matrix Proteins - metabolism; Genes; Genomes; Hedgehog Proteins; Learning - physiology; Ligands; Lipoproteins; Low density lipoprotein receptors; Membrane Microdomains - metabolism; Multigene Family; Nerve Tissue Proteins; Nervous system; neurotransmission; Organisms; Protein Transport - physiology; Proteins; Proto-Oncogene Proteins - metabolism; Receptors, LDL - chemistry; Receptors, LDL - genetics; Receptors, LDL - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Reelin; Serine Endopeptidases; Signal Transduction - physiology; signaling; Trans-Activators - metabolism; Wnt Proteins; Zebrafish Proteins
• ISSN: 0066-4154; 1545-4509
• DOI: 10.1146/annurev.biochem.71.110601.135342

The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.