A Microfluidic Diluter Based on Pulse Width Flow Modulation

• Published in: Analytical chemistry (Washington) Vol. 81; no. 13; pp. 5549 - 5556
• Main Authors: Ainla, Alar, Gözen, Irep, Orwar, Owe, Jesorka, Aldo
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.07.2009
• Subjects: Analytical chemistry; bilayers; biosensors; Calcium - chemistry; Chemical compounds; Chemistry; device; dynamic chemical signals; Exact sciences and technology; Fluids; Fluorescent Dyes - chemistry; generation; Hydraulics; hydrophilic surfaces; Indicator Dilution Techniques - instrumentation; Lipid Bilayers - metabolism; liposomes; Membranes; Microfluidics - instrumentation; Microfluidics - methods; nanoliter-scale; networks; Silicon Dioxide - chemistry; Fluid mechanics; Dilution; Phospholipid; Membrane; Bilayer; Pulse modulation; Microfluidics; Mold; Variance

We demonstrate that pulse width flow modulation (PWFM) can be used to design fast, accurate, and precise multistage dilution modules for microfluidic devices. The PWFM stage unit presented here yields 10-fold dilution, but several PWFM stages can be connected in series to yield higher-order dilution...