The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

• Published in: Chemical reviews Vol. 121; no. 24; pp. 14682 - 14905
• Main Authors: Lehnert, Nicolai, Kim, Eunsuk, Dong, Hai T, Harland, Jill B, Hunt, Andrew P, Manickas, Elizabeth C, Oakley, Kady M, Pham, John, Reed, Garrett C, Alfaro, Victor Sosa
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.12.2021
• Subjects: Biology; Biomimetics; Biosynthesis; Catalysts; Chemical reactions; Chemistry; Coordination compounds; Electronic structure; Electronics; Heme - chemistry; Hemeproteins; Iron; Iron - chemistry; Nitric oxide; Nitric Oxide - chemistry; Nitrogen Oxides - chemistry; Proteins; Reactivity; Reductases
• ISSN: 0009-2665; 1520-6890
• DOI: 10.1021/acs.chemrev.1c00253

Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of physiological and pathological events in biology. Metal coordination chemistry, especially with iron, is at the heart of many biological transformations involving NO. A series of heme proteins, nitric oxide synthases (NOS), soluble guanylate cyclase (sGC), and nitrophorins, are responsible for the biosynthesis, sensing, and transport of NO. Alternatively, NO can be generated from nitrite by heme- and copper-containing nitrite reductases (NIRs). The NO-bearing small molecules such as nitrosothiols and dinitrosyl iron complexes (DNICs) can serve as an alternative vehicle for NO storage and transport. Once NO is formed, the rich reaction chemistry of NO leads to a wide variety of biological activities including reduction of NO by heme or non-heme iron-containing NO reductases and protein post-translational modifications by DNICs. Much of our understanding of the reactivity of metal sites in biology with NO and the mechanisms of these transformations has come from the elucidation of the geometric and electronic structures and chemical reactivity of synthetic model systems, in synergy with biochemical and biophysical studies on the relevant proteins themselves. This review focuses on recent advancements from studies on proteins and model complexes that not only have improved our understanding of the biological roles of NO but also have provided foundations for biomedical research and for bio-inspired catalyst design in energy science.