How Rhizobia Adapt to the Nodule Environment

• Published in: Journal of bacteriology Vol. 203; no. 12; pp. 1 - 18
• Main Authors: Ledermann, Raphael, Schulte, Carolin C. M., Poole, Philip S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 20.05.2021
• Subjects: Adaptation; Bacteria; Bacteriology; Bacteroids; Computer applications; Genetics; Legumes; Minireview; Nitrogen fixation; Nitrogenation; Nodules; Organs; Phylogeny; Soil bacteria; Soil microorganisms; Symbiosis; microaerobiosis; modeling; root nodule; host sanctioning; growth arrest; metabolism; nitrogen fixation; rhizobium-legume symbiosis
• ISSN: 0021-9193; 1098-5530; 1098-5530
• DOI: 10.1128/JB.00539-20

Rhizobia are a phylogenetically diverse group of soil bacteria that engage in mutualistic interactions with legume plants. Although specifics of the symbioses differ between strains and plants, all symbioses ultimately result in the formation of specialized root nodule organs that host the nitrogen-fixing microsymbionts called bacteroids. Rhizobia are a phylogenetically diverse group of soil bacteria that engage in mutualistic interactions with legume plants. Although specifics of the symbioses differ between strains and plants, all symbioses ultimately result in the formation of specialized root nodule organs that host the nitrogen-fixing microsymbionts called bacteroids. Inside nodules, bacteroids encounter unique conditions that necessitate the global reprogramming of physiological processes and the rerouting of their metabolism. Decades of research have addressed these questions using genetics, omics approaches, and, more recently, computational modeling. Here, we discuss the common adaptations of rhizobia to the nodule environment that define the core principles of bacteroid functioning. All bacteroids are growth arrested and perform energy-intensive nitrogen fixation fueled by plant-provided C 4 -dicarboxylates at nanomolar oxygen levels. At the same time, bacteroids are subject to host control and sanctioning that ultimately determine their fitness and have fundamental importance for the evolution of a stable mutualistic relationship.