Mutation of RNA Polymerase β-Subunit Gene Promotes Heterogeneous-to-Homogeneous Conversion of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus

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Published inAntimicrobial Agents and Chemotherapy Vol. 57; no. 10; pp. 4861 - 4871
Main Authors AIBA, Yoshifumi, KATAYAMA, Yuki, HISHINUMA, Tomomi, MURAKAMI-KURODA, Hiroko, LONGZHU CUI, HIRAMATSU, Keiichi
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2013
Subjects
Amino acids
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
beta-Lactam Resistance - genetics
beta-Lactam Resistance - physiology
Biological and medical sciences
Blotting, Western
DNA-Directed RNA Polymerases
DNA-Directed RNA Polymerases - genetics
Human bacterial diseases
Infectious diseases
Mechanisms of Resistance
Medical sciences
Methicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - enzymology
Methicillin-Resistant Staphylococcus aureus - genetics
Microscopy, Electron, Transmission
Molecular Sequence Data
Mutation, Missense - genetics
Pharmacology. Drug treatments
Polymorphism, Single Nucleotide - genetics
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Enzyme
Transferases
β-Lactams
Subunit
Conversion
DNA-directed RNA polymerase
Infection
Resistance
Nucleotidyltransferases
Gene
Bacteriosis
Bacteria
Micrococcales
Genetics
Micrococcaceae
Mutation
Antibacterial agent
Staphylococcal infection
Staphylococcus aureus
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Summary:OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Present address: Longzhu Cui, Research Center for Infections and Antimicrobials, Kitasato Institute for Life Science, Kitasato University, Tokyo, Japan.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00720-13