Human Monoclonal Antibodies against Clostridium difficile Toxins A and B Inhibit Inflammatory and Histologic Responses to the Toxins in Human Colon and Peripheral Blood Monocytes

• Published in: Antimicrobial Agents and Chemotherapy Vol. 57; no. 7; pp. 3214 - 3223
• Main Authors: HON WAI KOON, SHIH, David Q, HING, Tressia C, JUN HWAN YOO, HO, Samantha, XINHUA CHEN, KELLY, Ciarán P, TARGAN, Stephan R, POTHOULAKIS, Charalabos
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2013
• Subjects: Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antibodies, Monoclonal; Antibodies, Monoclonal - immunology; Bacterial Proteins; Bacterial Proteins - immunology; Bacterial Toxins; Bacterial Toxins - immunology; Biological and medical sciences; Cells, Cultured; Clostridium difficile; Clostridium difficile - immunology; Colon - drug effects; Colon - immunology; Enterocolitis, Pseudomembranous - drug therapy; Enterocolitis, Pseudomembranous - prevention & control; Enterotoxins; Enterotoxins - immunology; Experimental Therapeutics; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Inflammation - immunology; Inflammation - prevention & control; Interleukin-1beta - biosynthesis; Intestinal Mucosa; Intestinal Mucosa - drug effects; Intestinal Mucosa - immunology; Leukocytes, Mononuclear - drug effects; Medical sciences; Other diseases. Semiology; Pharmacology. Drug treatments; Phosphorylation; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transcription Factor RelA - metabolism; Tumor Necrosis Factor-alpha - biosynthesis; Human; Monocyte; Digestive system; Peripheral blood circulation; Clostridium difficile; Clostridiales; Diarrhea; Histology; Inflammation; Monoclonal antibody; Toxin; Clostridiaceae; Bacteria; Digestive diseases; Intestinal disease; Inhibitor; Colon
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02633-12

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