Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Ceftolozane in an In Vitro Infection Model

• Published in: Antimicrobial Agents and Chemotherapy Vol. 57; no. 6; pp. 2809 - 2814
• Main Authors: VANSCOY, Brian, MENDES, Rodrigo E, STEENBERGEN, Judith N, AMBROSE, Paul G, NICASIO, Anthony M, CASTANHEIRA, Mariana, BULIK, Catharine C, OKUSANYA, Olanrewaju O, BHAVNANI, Sujata M, FORREST, Alan, JONES, Ronald N, FRIEDRICH, Lawrence V
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2013
• Subjects: Anti-Bacterial Agents; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; beta-Lactamases; beta-Lactamases - biosynthesis; beta-Lactamases - genetics; Biological and medical sciences; Cephalosporins; Cephalosporins - administration & dosage; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Cephalosporins - therapeutic use; Dose-Response Relationship, Drug; Drug Therapy, Combination; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - enzymology; Escherichia coli - genetics; Escherichia coli - growth & development; Escherichia coli Infections; Escherichia coli Infections - drug therapy; Escherichia coli Infections - microbiology; Humans; Medical sciences; Microbial Sensitivity Tests; Models, Biological; Molecular Sequence Data; Penicillanic Acid; Penicillanic Acid - administration & dosage; Penicillanic Acid - analogs & derivatives; Penicillanic Acid - pharmacokinetics; Penicillanic Acid - pharmacology; Penicillanic Acid - therapeutic use; Pharmacology; Pharmacology. Drug treatments; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Drug combination; Pharmacodynamics; Enzyme; Enzyme inhibitor; β-Lactamase; In vitro; Biological activity; Infection; Tazobactam; Ceftolozane; Hydrolases; Models; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02513-12

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