Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum β-Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model

• Published in: Antimicrobial Agents and Chemotherapy Vol. 57; no. 5; pp. 2109 - 2113
• Main Authors: DOCOBO-PEREZ, F, LOPEZ-CERERO, L, LOPEZ-ROJAS, R, EGEA, P, DOMINGUEZ-HERRERA, J, RODRIGUEZ-BANO, J, PASCUAL, A, PACHON, J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2013
• Subjects: Amoxicillin-Potassium Clavulanate Combination; Amoxicillin-Potassium Clavulanate Combination - pharmacology; Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial diseases; Bacterial sepsis; beta-Lactamases - metabolism; Biological and medical sciences; Colony Count, Microbial; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - enzymology; Escherichia coli - growth & development; Escherichia coli Infections; Escherichia coli Infections - drug therapy; Escherichia coli Infections - microbiology; Experimental Therapeutics; Female; Human bacterial diseases; Imipenem; Imipenem - pharmacology; Infectious diseases; Injections, Intramuscular; Injections, Intraperitoneal; Intraabdominal Infections; Intraabdominal Infections - drug therapy; Intraabdominal Infections - microbiology; Medical sciences; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Penicillanic Acid - analogs & derivatives; Penicillanic Acid - pharmacology; Pharmacology. Drug treatments; Piperacillin - pharmacology; Sepsis; Sepsis - drug therapy; Sepsis - microbiology; Treatment Outcome; Animal model; Clavulanic acid; Escherichia coli; Extended-spectrum β-lactamase; Penicillin derivatives; Sepsis syndrome; Carbapenem derivatives; Piperacillin; Bacteria; Enterobacteriaceae; β-Lactams; Treatment efficiency; Rodentia; Enzyme inhibitor; Bacteremia; Infection; Vertebrata; Antibiotic; Mammalia; Mouse; Tazobactam; Amoxicillin; Bacteriosis; Antibacterial agent; Imipenem
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02190-12

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