Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly...

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Bibliographic Details
Published inACS central science Vol. 6; no. 3; pp. 404 - 412
Main Authors Wei, Lixia, Zhao, Yu, Hu, Xiaomeng, Tang, Li
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.03.2020
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Summary:A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge.
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ISSN:2374-7943
2374-7951
DOI:10.1021/acscentsci.9b01174