Healthy diet intervention reverses the progression of NASH through gut microbiota modulation

• Published in: Microbiology spectrum Vol. 12; no. 1; p. e0186823
• Main Authors: Panyod, Suraphan, Wu, Wei-Kai, Hu, Meng-Yun, Huang, Huai-Syuan, Chen, Rou-An, Chen, Yi-Hsun, Shen, Ting-Chin David, Ho, Chi-Tang, Liu, Chun-Jen, Chuang, Hsiao-Li, Huang, Chi-Chang, Wu, Ming-Shiang, Sheen, Lee-Yan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 11.01.2024
• Subjects: Diet, Healthy; Diet, High-Fat - adverse effects; Food Microbiology; GAN diet; Gastrointestinal Microbiome; ginger essential oil; gut microbiome; Humans; inflammasome; Liver - metabolism; Non-alcoholic Fatty Liver Disease - drug therapy; non-alcoholic steatohepatitis; obeticholic acid; Research Article; obeticholic acid; gut microbiome; GAN diet; ginger essential oil; inflammasome; LPS; non-alcoholic steatohepatitis
• ISSN: 2165-0497; 2165-0497
• DOI: 10.1128/spectrum.01868-23

The link between gut microbiota and diet is crucial in the development of non-alcoholic steatohepatitis (NASH). This study underscores the essential role of a healthy diet in preventing and treating NASH by reversing obesity, lipidemia, and gut microbiota dysbiosis. Moreover, the supplementation of functional food or drug to the diet can provide additional advantages by inhibiting hepatic inflammation through the modulation of the hepatic inflammasome signaling pathway and partially mediating the gut microbiota and lipopolysaccharide signaling pathway. This study highlights the importance of adopting healthy dietary habits in treating NASH and proposes that supplementing with ginger essential oil or obeticholic acid may offer additional benefits. Nonetheless, further clinical studies are necessary to validate these findings.