Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes

• Published in: Microbiology spectrum Vol. 11; no. 6; p. e0274323
• Main Authors: Charria-Girón, Esteban, Marin-Felix, Yasmina, Beutling, Ulrike, Franke, Raimo, Brönstrup, Mark, Vasco-Palacios, Aida M, Caicedo, Nelson H, Surup, Frank
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 12.12.2023
• Subjects: antibiotics; Antimicrobial Chemotherapy; metabolomics; natural products; NMR; Research Article; secondary metabolites; structure elucidation; natural products; NMR; secondary metabolites; metabolomics; dereplication; structure elucidation; antibiotics

The integration of metabolomics-based approaches into the discovery pipeline has enabled improved mining and prioritization of prolific secondary metabolite producers such as endophytic fungi. However, relying on automated untargeted analysis tools might lead to misestimation of the chemical complex...