Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes

The integration of metabolomics-based approaches into the discovery pipeline has enabled improved mining and prioritization of prolific secondary metabolite producers such as endophytic fungi. However, relying on automated untargeted analysis tools might lead to misestimation of the chemical complex...

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Published inMicrobiology spectrum Vol. 11; no. 6; p. e0274323
Main Authors Charria-Girón, Esteban, Marin-Felix, Yasmina, Beutling, Ulrike, Franke, Raimo, Brönstrup, Mark, Vasco-Palacios, Aida M, Caicedo, Nelson H, Surup, Frank
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 12.12.2023
Subjects
antibiotics
Antimicrobial Chemotherapy
metabolomics
natural products
NMR
Research Article
secondary metabolites
structure elucidation
natural products
NMR
secondary metabolites
metabolomics
dereplication
structure elucidation
antibiotics
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Summary:The integration of metabolomics-based approaches into the discovery pipeline has enabled improved mining and prioritization of prolific secondary metabolite producers such as endophytic fungi. However, relying on automated untargeted analysis tools might lead to misestimation of the chemical complexity harbored in these organisms. Our study emphasizes the importance of isolation and structure elucidation of the respective metabolites in addition to deep metabolome analysis for the correct interpretation of untargeted metabolomics approaches such as molecular networking. Additionally, it encourages the further exploration of endophytic fungi from traditional medicinal plants for the discovery of natural products.
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02743-23