Antigenic Variation in H5N1 clade 2.1 Viruses in Indonesia From 2005 to 2011

• Published in: Virology : research and treatment Vol. 2013; no. 2013; pp. 27 - 34
• Main Authors: Setiawaty, Vivi, Pratiwi, Eka, Pawestri, Hana A., Ibrahim, Fera, Soebandrio, Amin
• Format: Journal Article
• Language: English
• Published: London, England Libertas Academica 01.01.2013; SAGE Publishing; SAGE Publications; Sage Publications Ltd. (UK); Sage Publications Ltd
• Subjects: Amino acids; Analysis; Avian influenza; Genetic aspects; Genetic variation; Original Research; Indonesia; H5N1; Antigenic; Antibody; Cross-reactivity
• ISSN: 1178-122X; 1178-122X
• DOI: 10.4137/VRT.S11754

Influenza A (H5N1) virus, has spread to several countries in the world and has a high mortality rate. Meanwhile, the virus has evolved into several clades. The human influenza A (H5N1) virus circulating in Indonesia is a member of clade 2.1, which is different in antigenicity from other clades of influenza A (H5N1). An analysis of the antigenic variation in the H5 hemagglutinin gene (HA) of the influenza A (H5N1) virus strains circulating in Indonesia has been undertaken. Several position of amino acid mutations, including mutations at positions 35, 53, 141, 145, 163, 174, 183, 184, 189, and 231, have been identified. The mutation Val-174-Iso appears to play an important role in immunogenicity and cross-reactivity with rabbit antisera. This study shows that the evolution of the H5HA antigenic variation of the influenza A (H5N1) virus circulating in Indonesia from 2005 to 2011 may affect the immunogenicity of the virus.