Interaction Study of the Combined Use of Paroxetine and Fosamprenavir-Ritonavir in Healthy Subjects

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 11; pp. 4098 - 4104
• Main Authors: VAN DER LEE, Manon J, BLENKE, Audrey A. M, RONGEN, Gerard A, VERWEY-VAN WISSEN, Corrien P. W. G. M, KOOPMANS, Peter P, PHARO, Cristina, BURGER, David M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2007; American Society for Microbiology (ASM)
• Subjects: Adolescent; Adult; Aged; Anti-HIV Agents - adverse effects; Anti-HIV Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - pharmacokinetics; Area Under Curve; Biological and medical sciences; Carbamates; Carbamates - adverse effects; Carbamates - pharmacokinetics; Drug Interactions; Female; Genotype; Humans; Male; Medical sciences; Metabolic Clearance Rate; Middle Aged; Organophosphates; Organophosphates - adverse effects; Organophosphates - pharmacokinetics; Paroxetine; Paroxetine - adverse effects; Paroxetine - pharmacokinetics; Pharmacology; Pharmacology. Drug treatments; Ritonavir; Ritonavir - adverse effects; Ritonavir - pharmacokinetics; Sulfonamides; Sulfonamides - adverse effects; Sulfonamides - pharmacokinetics; Human; Paroxetine; Antiretroviral agent; Serotonin; Healthy subject; Enzyme; Psychotropic; Ritonavir; Interaction; Enzyme inhibitor; Reuptake inhibitor; Selective serotonin reuptake inhibitor; Peptidases; Fosamprenavir; Piperidine derivatives; Neurotransmitter; Hydrolases; Antidepressant agent; Antiviral; Protease inhibitor
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01243-06

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