Spontaneous Deletion of the Methicillin Resistance Determinant, mecA, Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus

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Published inAntimicrobial Agents and Chemotherapy Vol. 52; no. 4; pp. 1221 - 1229
Main Authors NOTO, Michael J, FOX, Paige M, ARCHER, Gordon L
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2008
American Society for Microbiology (ASM)
Subjects
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial Proteins
Bacterial Proteins - genetics
Biological and medical sciences
Culture Media
Gene Deletion
Human bacterial diseases
Humans
Infectious diseases
Mechanisms of Resistance
Medical sciences
Methicillin Resistance
Methicillin Resistance - genetics
Microbial Sensitivity Tests
Penicillin-Binding Proteins
Pharmacology. Drug treatments
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - growth & development
Vancomycin Resistance
Costs
Peptides
β-Lactams
Spontaneous
Vancomycin
Meticillin
Penicillin derivatives
Infection
Resistance
Antibiotic
Glycopeptide
Polypeptide
Health economy
Bacteriosis
Deletion
Bacteria
Micrococcales
Micrococcaceae
Economic aspect
Mutation
Antibacterial agent
Staphylococcal infection
Staphylococcus aureus
Fitness
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Internal Medicine, Virginia Commonwealth University, P.O. Box 980565, 1101 East Marshall Street, Richmond, VA. 23298-0565. Phone: (804) 828-0678. Fax: (804) 828-5022. E-mail: garcher@vcu.edu
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01164-07