Escape of Candida from Caspofungin Inhibition at Concentrations above the MIC (Paradoxical Effect) Accomplished by Increased Cell Wall Chitin; Evidence for β-1,6-Glucan Synthesis Inhibition by Caspofungin

• Published in: Antimicrobial Agents and Chemotherapy Vol. 50; no. 9; pp. 3160 - 3161
• Main Authors: STEVENS, David A, ICHINOMIYA, Masayuki, KOSHI, Yukako, HORIUCHI, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2006
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - pharmacology; beta-Glucans; beta-Glucans - metabolism; Biological and medical sciences; Candida; Candida albicans; Candida albicans - drug effects; Candida albicans - growth & development; Candida albicans - isolation & purification; Candida albicans - metabolism; Cell Wall - metabolism; Chitin; Chitin - metabolism; Echinocandins; Lipopeptides; Mechanisms of Action: Physiological Effects; Medical sciences; Microbial Sensitivity Tests; Peptides, Cyclic; Peptides, Cyclic - pharmacology; Pharmacology. Drug treatments; Candidiasis; Yeast; Mycosis; Chitin; Echinocandine derivatives; Cell wall; Fungi; Infection; Glucan; Antifungal agent; Synthesis; Candida; Caspofungin; Minimum inhibitory concentration; Inhibitor; Fungi Imperfecti; Thallophyta
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00563-06

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