Tipranavir (TPV) Genotypic Inhibitory Quotient Predicts Virological Response at 48 Weeks to TPV-Based Salvage Regimens

• Published in: Antimicrobial Agents and Chemotherapy Vol. 52; no. 3; pp. 1066 - 1071
• Main Authors: DE REQUENA, Daniel Gonzalez, BONORA, Stefano, BAIETTO, Lorena, TRENTINI, Laura, DI PERRI, Giovanni, CALCAGNO, Andrea, D'AVOLIO, Antonio, SICCARDI, Marco, FONTANA, Silvia, GRAZIA MILIA, Maria, SCIANDRA, Mauro, GARAZZINO, Silvia, DI GARBO, Antonio
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2008; American Society for Microbiology (ASM)
• Subjects: Adult; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Drug Resistance, Viral - genetics; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV Infections - drug therapy; HIV Infections - virology; HIV Protease; HIV Protease - genetics; HIV Protease Inhibitors; HIV Protease Inhibitors - pharmacokinetics; HIV Protease Inhibitors - pharmacology; HIV Protease Inhibitors - therapeutic use; HIV-1; HIV-1 - drug effects; HIV-1 - enzymology; HIV-1 - genetics; Humans; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Pharmacology. Drug treatments; Predictive Value of Tests; Pyridines; Pyridines - pharmacokinetics; Pyridines - pharmacology; Pyridines - therapeutic use; Pyrones; Pyrones - pharmacokinetics; Pyrones - pharmacology; Pyrones - therapeutic use; Reverse Transcriptase Inhibitors - therapeutic use; Ritonavir - pharmacology; Ritonavir - therapeutic use; Salvage Therapy; Treatment Outcome; Peptidases; Tipranavir; Enzyme; Enzyme inhibitor; Non peptide compound; Hydrolases; Antiviral; Genotype; Salvage treatment; Predictive factor; Protease inhibitor
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01063-07

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