Evaluation of WLBU2 Peptide and 3-O-Octyl-sn-Glycerol Lipid as Active Ingredients for a Topical Microbicide Formulation Targeting Chlamydia trachomatis

• Published in: Antimicrobial Agents and Chemotherapy Vol. 54; no. 2; pp. 627 - 636
• Main Authors: SKINNER, M. C, KISELEV, A. O, ISAACS, C. E, MIETZNER, T. A, MONTELARO, R. C, LAMPE, M. F
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2010; American Society for Microbiology (ASM)
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents, Local; Anti-Infective Agents, Local - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial Cationic Peptides; Antimicrobial Cationic Peptides - pharmacology; Bacterial diseases; Bacterial diseases of the genital system; Biological and medical sciences; Cell Line; Chlamydia trachomatis; Chlamydia trachomatis - drug effects; Chlamydia trachomatis - physiology; Drug Synergism; Epidemiology. Vaccinations; Female; General aspects; Glyceryl Ethers; Glyceryl Ethers - pharmacology; Human bacterial diseases; Humans; Hydrogen-Ion Concentration; Infectious diseases; L-Lactate Dehydrogenase - metabolism; Male; Medical sciences; Mice; Microbial Sensitivity Tests; Penicillin G - pharmacology; Pharmacology. Drug treatments; Polymyxin B - pharmacology; Susceptibility; Tetrazolium Salts - chemistry; Thiazoles - chemistry; Evaluation; Chlamydiaceae; Targeting; Peptides; Glycerol; Lipids; Chlamydia trachomatis; Antimicrobial agent; Infection; Local administration; Target; Sexually transmitted disease; Formulation; Chlamydiales; Dosage form; Bacteria; Active ingredient; Topical administration
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00635-09

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