Steady-State Disposition of the Nonpeptidic Protease Inhibitor Tipranavir when Coadministered with Ritonavir

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 7; pp. 2436 - 2444
• Main Authors: Chen, Linzhi, Sabo, John P., Philip, Elsy, Mao, Yanping, Norris, Stephen H., MacGregor, Thomas R., Wruck, Jan M., Garfinkel, Sandra, Castles, Mark, Brinkman, Amy, Valdez, Hernan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2007; American Society for Microbiology (ASM)
• Subjects: Administration, Oral; Anti-HIV Agents; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - adverse effects; Anti-HIV Agents - blood; Anti-HIV Agents - metabolism; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - urine; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Capsules; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Feces - chemistry; HIV Protease Inhibitors; HIV Protease Inhibitors - administration & dosage; HIV Protease Inhibitors - adverse effects; HIV Protease Inhibitors - blood; HIV Protease Inhibitors - metabolism; HIV Protease Inhibitors - pharmacokinetics; HIV Protease Inhibitors - urine; Humans; Male; Medical sciences; Pharmacology; Pharmacology. Drug treatments; Pyridines; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - blood; Pyridines - metabolism; Pyridines - pharmacokinetics; Pyridines - urine; Pyrones; Pyrones - administration & dosage; Pyrones - adverse effects; Pyrones - blood; Pyrones - metabolism; Pyrones - pharmacokinetics; Pyrones - urine; Ritonavir; Ritonavir - administration & dosage; Ritonavir - adverse effects; Ritonavir - blood; Ritonavir - metabolism; Ritonavir - pharmacokinetics; Ritonavir - urine; Peptidases; Antiretroviral agent; Tipranavir; Enzyme; Ritonavir; Enzyme inhibitor; Hydrolases; Antiviral; Non peptide compound; Pharmacokinetics; Protease inhibitor
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01115-06

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