Bioactive Compounds from Bauhinia purpurea Possessing Antimalarial, Antimycobacterial, Antifungal, Anti-inflammatory, and Cytotoxic Activities

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 5; pp. 795 - 801
• Main Authors: Boonphong, Surat, Puangsombat, Pakawan, Baramee, Apiwat, Mahidol, Chulabhorn, Ruchirawat, Somsak, Kittakoop, Prasat
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.05.2007; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; antibacterial properties; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; antifungal properties; antimalarials; Antimalarials - chemistry; Antimalarials - isolation & purification; Antimalarials - pharmacology; bauhibenzofurin; Bauhinia - chemistry; Bauhinia purpurea; bauhinol; bauhinoxepin; bauhispirorin; Benzoxepins - chemistry; Benzoxepins - isolation & purification; Benzoxepins - pharmacology; Bibenzyls - chemistry; Bibenzyls - isolation & purification; Bibenzyls - pharmacology; Biological and medical sciences; Candida albicans; chemical structure; Chemistry, Medicinal; cytotoxicity; demethoxymatteucinol; dihydrobenzofuran; dihydrodibenzoxepin; Fabaceae; Flavanones - chemistry; Flavanones - isolation & purification; Flavanones - pharmacology; furans; General pharmacology; heterocyclic compounds; Life Sciences & Biomedicine; Medical sciences; medicinal properties; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Plasmodium falciparum; Science & Technology; secondary metabolites; spectral analysis; Spiro Compounds - chemistry; Spiro Compounds - isolation & purification; Spiro Compounds - pharmacology; spirochromane-2,1'-hexenedione; strobopinin; Thailand; Thailand; BIBENZYLS; ASSAY; PHENOL; STILBENOIDS; BIOSYNTHESIS; RACEMOSOL; FLAVONOIDS; AGENTS; BINDING; STEM; Antineoplastic agent; Antimalarial; Metabolite; Cytotoxicity; Biosynthesis; Extract; Oxygen heterocycle; Medicinal plant; Antiprotozoal agent; Antifungal agent; Dicotyledones; Angiospermae; Bicyclic compound; Antituberculous agent; Aromatic compound; Secondary metabolism; Below ground plant part; Root; Pharmacognosy; Quinone; Antiinflammatory agent; Tricyclic compound; In vitro; Biological activity; Spiran; Leguminosae; Plant origin; Phenols; Parasiticide; Benzenic compound; Isolation; Spermatophyta; Benzofuran derivatives; Antibacterial agent; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np070010e

Eleven new secondary metabolites (1−11), together with two known flavanones (12 and 13) and five known bibenzyls (14−18), were isolated from the root extract of Bauhinia purpurea. New compounds include eight dihydrodibenzoxepins (1−8), a dihydrobenzofuran (9), a novel spirochromane-2,1‘-hexenedione (10), and a new bibenzyl (11). Antimycobacterial, antimalarial, antifungal, cytotoxic, and anti-inflammatory activities of the isolated compounds are reported, and biosynthetic pathways of these compounds are also discussed.