The Microbiome and Human Biology
Over the past few years, microbiome research has dramatically reshaped our understanding of human biology. New insights range from an enhanced understanding of how microbes mediate digestion and disease processes (e.g., in inflammatory bowel disease) to surprising associations with Parkinson's...
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Published in | Annual review of genomics and human genetics Vol. 18; no. 1; pp. 65 - 86 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Annual Reviews
31.08.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Over the past few years, microbiome research has dramatically reshaped our understanding of human biology. New insights range from an enhanced understanding of how microbes mediate digestion and disease processes (e.g., in inflammatory bowel disease) to surprising associations with Parkinson's disease, autism, and depression. In this review, we describe how new generations of sequencing technology, analytical advances coupled to new software capabilities, and the integration of animal model data have led to these new discoveries. We also discuss the prospects for integrating studies of the microbiome, metabolome, and immune system, with the goal of elucidating mechanisms that govern their interactions. This systems-level understanding will change how we think about ourselves as organisms. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
ISSN: | 1527-8204 1545-293X |
DOI: | 10.1146/annurev-genom-083115-022438 |