Efficacy of the Novel Diamidine Compound 2,5-Bis(4-Amidinophenyl)- Furan-Bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense Infection in Vervet Monkeys after Oral Administration

• Published in: Antimicrobial Agents and Chemotherapy Vol. 53; no. 3; pp. 953 - 957
• Main Authors: Mdachi, R E, Thuita, J K, Kagira, J M, Ngotho, J M, Murilla, G A, Ndung'u, J M, Tidwell, R R, Hall, J E, Brun, R
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2009; American Society for Microbiology (ASM)
• Subjects: Administration, Oral; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Benzamidines; Benzamidines - administration & dosage; Benzamidines - therapeutic use; Biological and medical sciences; Cercopithecus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Experimental Therapeutics; Female; Male; Medical sciences; Pentamidine; Pentamidine - administration & dosage; Pentamidine - therapeutic use; Pharmacology. Drug treatments; Prodrugs; Prodrugs - administration & dosage; Prodrugs - therapeutic use; Random Allocation; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanocidal Agents - administration & dosage; Trypanocidal Agents - therapeutic use; Trypanosoma brucei rhodesiense; Trypanosoma brucei rhodesiense - drug effects; Trypanosomiasis, African; Trypanosomiasis, African - drug therapy; Kinetoplastida; Protozoa; Furan; Treatment efficiency; Monkey; Oral administration; Pafuramidine; Infection; Vertebrata; Mammalia; Animal; Trypanosoma rhodesiense; Primates; Parasiticide; Trypanosoma brucei
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00831-08

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