High-Level Expression of Chromosomally Encoded SHV-1 β-Lactamase and an Outer Membrane Protein Change Confer Resistance to Ceftazidime and Piperacillin- Tazobactam in a Clinical Isolate of Klebsiella pneumoniae

• Published in: Antimicrobial Agents and Chemotherapy Vol. 44; no. 2; pp. 362 - 367
• Main Authors: RICE, L. B, CARIAS, L. L, HUJER, A. M, BONAFEDE, M, HUTTON, R, HOYEN, C, BONOMO, R. A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2000
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Outer Membrane Proteins; Bacterial Outer Membrane Proteins - biosynthesis; Bacterial Outer Membrane Proteins - metabolism; Base Sequence; beta-Lactamases; beta-Lactamases - biosynthesis; beta-Lactamases - genetics; Biological and medical sciences; Biological Transport; Ceftazidime; Ceftazidime - pharmacology; Cephalosporins - pharmacology; Chromosomes; Cloning, Molecular; DNA, Bacterial - analysis; Drug Resistance, Microbial - genetics; Drug Resistance, Microbial - physiology; Enzyme Inhibitors - pharmacology; Gene Expression Regulation, Bacterial - drug effects; Humans; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - metabolism; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleic Acid Hybridization; Penicillanic Acid; Penicillanic Acid - analogs & derivatives; Penicillanic Acid - pharmacology; Penicillins - pharmacology; Pharmacology. Drug treatments; Piperacillin; Piperacillin - pharmacology; Promoter Regions, Genetic - genetics; Sequence Homology, Nucleic Acid; Tazobactam; Molecular hybridization; Membrane protein; Enzyme; β-Lactams; Site directed mutagenesis; β-Lactamase; Gene expression; In vitro; Plasmid; Penicillin derivatives; Resistance; Antibiotic; Cephalosporin derivatives; Tazobactam; Piperacillin; Bacteria; Hydrolases; Genetics; Conjugation; Antibacterial agent; Molecular cloning; Ceftazidime; Klebsiella pneumoniae; Enterobacteriaceae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.44.2.362-367.2000

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