Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanop...

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Bibliographic Details
Published inNano letters Vol. 10; no. 7; pp. 2543 - 2548
Main Authors Arvizo, Rochelle R, Miranda, Oscar R, Thompson, Michael A, Pabelick, Christina M, Bhattacharya, Resham, Robertson, J. David, Rotello, Vincent M, Prakash, Y. S, Mukherjee, Priyabrata
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 14.07.2010
Subjects
Apoptosis
Biological Transport
Calcium - metabolism
Cell Line
Cell Line, Tumor
Cell Membrane - metabolism
Cell Proliferation
Cross-disciplinary physics: materials science; rheology
Exact sciences and technology
Gold - chemistry
Humans
Materials science
Membrane Potentials
Metal Nanoparticles - chemistry
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Physics
Static Electricity
apoptosis
cancer
calcium
surface properties
Gold nanoparticles
membrane potential
Nanoparticles
Gold
Surface charge
Nanostructured materials
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Summary:Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl101140t