Novel Polycyclic Guanidine Alkaloids from Two Marine Sponges of the Genus Monanchora

• Published in: Journal of natural products (Washington, D.C.) Vol. 63; no. 2; pp. 193 - 196
• Main Authors: Braekman, J. C, Daloze, D, Tavares, R, Hajdu, E, Van Soest, R. W. M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.02.2000; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: alkaloids; Alkaloids - chemistry; Animals; Biological and medical sciences; chemical composition; chemical structure; Chemistry, Medicinal; crambescidins; Dehydrobatzelladine C; General pharmacology; guanidine alkaloids; guanidines; Guanidines - chemistry; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Marine; Medical sciences; Molecular Conformation; Monanchora arbuscula; Monanchora unguiculata; natural products; parazoa; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Porifera - chemistry; Science & Technology; secondary metabolites; spectral analysis; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Belize; Central America; America; BATZELLA SP; CRAMBE-CRAMBE; PTILOMYCALIN-A; CRAMBESCIDIN-800; ARBUSCULA; Marine environment; Alkaloid; Porifera; Angular nitrogen heterocycle; Pharmacognosy; Animal origin; Isolation; Guanidines; Invertebrata; Spiran; Structural analysis; Oxygen nitrogen heterocycle
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np990403g

Two marine sponges of the genus Monanchora (Poecilosclerida, Crambeidae) have been found to contain new polycyclic guanidine alkaloids bearing the (5,6,8b)-triazaperhydroacenaphthylene skeleton. Their structures have been determined by detailed spectroscopic analysis. Dehydrobatzelladine C (1) has been isolated from M. arbuscula and crambescidins 359 (2) and 431 (3) from M. unguiculata. The chemotaxonomic implications of these findings are discussed.