Excavatolides F−M, New Briarane Diterpenes from the Gorgonian Briareum excavatum

• Published in: Journal of natural products (Washington, D.C.) Vol. 62; no. 3; pp. 457 - 463
• Main Authors: Sung, Ping-Jyun, Su, Jui-Hsin, Wang, Guey-Horng, Lin, Sung-Fang, Duh, Chang-Yih, Sheu, Jyh-Horng
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.1999; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Biological and medical sciences; Briareum excavatum; chemical composition; chemical structure; Chemistry, Medicinal; Cnidaria - chemistry; corals; cytotoxic compounds; Diterpenes - chemistry; Diterpenes - isolation & purification; diterpenoids; Drug Screening Assays, Antitumor; General pharmacology; Gorgonacea; HT29 Cells; Humans; KB Cells; Leukemia P388 - pathology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Marine; Medical sciences; Models, Molecular; Nitroblue Tetrazolium; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Science & Technology; spectral analysis; Spectrophotometry, Infrared; stereochemistry; Tumor Cells, Cultured; Taiwan; Asia; AUSTRALIAN SOFT CORALS; INSECTICIDAL DITERPENES; GORGONACEA; NATURAL-PRODUCTS; OCTOCORALLIA; STEREOCHEMISTRY; Antineoplastic agent; Human; Terpenoid; Pharmacognosy; Lung; P388-Leukemia; Animal origin; Cytotoxicity; Lactone; Biological activity; Marine environment; Coelenterata; Cell line; KB cell line; Cnidaria; Epoxide; Diterpene; Isolation; Colon; Invertebrata; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np980446h

Eight new briarane-type diterpenes, excavatolides F−M (1−8), have been isolated from the gorgonian Briareum excavatum. The structures and relative stereochemistry of these compounds were established by spectral analysis and chemical methods. The cytotoxicity of these compounds toward various cancer cell lines has also been determined.