Intranasal Interleukin-12 Treatment Promotes Antimicrobial Clearance and Survival in Pulmonary Francisella tularensis subsp. novicida Infection

• Published in: Antimicrobial Agents and Chemotherapy Vol. 48; no. 12; pp. 4513 - 4519
• Main Authors: PAMMIT, Michael A, BUDHAVARAPU, Varija N, RAULIE, Erin K, KLOSE, Karl E, TEALE, Judy M, ARULANANDAM, Bernard P
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2004
• Subjects: Adjuvants, Immunologic; Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - pharmacology; Administration, Intranasal; Animals; Anti-Bacterial Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Experimental Therapeutics; Female; Francisella tularensis; Gentamicins - therapeutic use; Interferon-gamma - therapeutic use; Interleukin-12; Interleukin-12 - administration & dosage; Interleukin-12 - pharmacology; Lung; Lung - microbiology; Medical sciences; Mice; Mice, Inbred BALB C; Phagocytosis - drug effects; Pharmacology. Drug treatments; Survival Analysis; Tularemia; Tularemia - drug therapy; Tularemia - microbiology; Treatment; Lung; Cytokine; Bacteria; Interleukin 12; Intranasal administration; Clearance; Pharmacokinetics; Survival; Antimicrobial agent; Francisella tularensis

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