Intranasal Interleukin-12 Treatment Promotes Antimicrobial Clearance and Survival in Pulmonary Francisella tularensis subsp. novicida Infection

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Published inAntimicrobial Agents and Chemotherapy Vol. 48; no. 12; pp. 4513 - 4519
Main Authors PAMMIT, Michael A, BUDHAVARAPU, Varija N, RAULIE, Erin K, KLOSE, Karl E, TEALE, Judy M, ARULANANDAM, Bernard P
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.2004
Subjects
Adjuvants, Immunologic
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Administration, Intranasal
Animals
Anti-Bacterial Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Experimental Therapeutics
Female
Francisella tularensis
Gentamicins - therapeutic use
Interferon-gamma - therapeutic use
Interleukin-12
Interleukin-12 - administration & dosage
Interleukin-12 - pharmacology
Lung
Lung - microbiology
Medical sciences
Mice
Mice, Inbred BALB C
Phagocytosis - drug effects
Pharmacology. Drug treatments
Survival Analysis
Tularemia
Tularemia - drug therapy
Tularemia - microbiology
Treatment
Lung
Cytokine
Bacteria
Interleukin 12
Intranasal administration
Clearance
Pharmacokinetics
Survival
Antimicrobial agent
Francisella tularensis
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Department of Biology, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249. Phone: (210) 458-5492. Fax: (210) 458-5523. E-mail: barulanandam@utsa.edu.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.48.12.4513-4519.2004