Toward Understanding the Biochemical Determinants of Protein Degradation Rates

Protein degradation is a key component of the regulation of gene expression and is at the center of several pathogenic processes. Proteins are regularly degraded, but there is large variation in their lifetimes, and the kinetics of protein degradation are not well understood. Many different factors...

Full description

Saved in:
Bibliographic Details
Published inACS omega Vol. 6; no. 8; pp. 5091 - 5100
Main Authors Correa Marrero, Miguel, Barrio-Hernandez, Inigo
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 02.03.2021
Subjects
Mini-Review
Online AccessGet full text

Cover

More Information
Summary:Protein degradation is a key component of the regulation of gene expression and is at the center of several pathogenic processes. Proteins are regularly degraded, but there is large variation in their lifetimes, and the kinetics of protein degradation are not well understood. Many different factors can influence protein degradation rates, painting a highly complex picture. This has been partially unravelled in recent years thanks to invaluable advances in proteomics techniques. In this Mini-Review, we give a global vision of the determinants of protein degradation rates with the backdrop of the current understanding of proteolytic systems to give a contemporary view of the field.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.0c05318