Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K

• Published in: ACS omega Vol. 7; no. 10; pp. 8591 - 8600
• Main Authors: Yu, Chuanping, Sun, Xinyuan, Wang, Yan, Du, Shichao, Shu, Liang, Sun, Qilei, Xue, Fumin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.03.2022
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.1c06468

Metformin hydrochloride (MET·HCl) is one of the most widely used oral hypoglycemic drugs in the world. In addition to hypoglycemic effects, MET·HCl also has anti-inflammatory, anti-tumor, anti-aging, and other effects, showing good efficacy and safety of single and combined treatment. The solubility of MET·HCl in water, water + N,N-dimethylformamide, water + acetonitrile, and water + n-propanol was measured by the gravimetric method under atmospheric pressure at temperatures ranging from 283.15 to 323.15 K. The solubility of MET·HCl has a positive correlation with temperature and water content. The experimental solubility data in binary solvents was correlated by the modified Apelblat model, CNIBS/R-K model, Apelblat–Jouyban–Acree model, and λh model. By comparing the average ARD % values of the four models, it is found that the modified Apelblat model (ARD % = 1.26) provides better correlation. Hansen solubility parameters and apparent thermodynamic parameters were calculated to analyze the solubility behavior, indicating that the dissolution process is endothermic and entropically favorable.