Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

• Published in: Organic letters Vol. 16; no. 20; pp. 5250 - 5253
• Main Authors: Guo, Chun-Jun, Sun, Wei-Wen, Bruno, Kenneth S, Wang, Clay C. C
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.10.2014
• Subjects: Aspergillus - chemistry; Aspergillus - genetics; Aspergillus terreus; BASIC BIOLOGICAL SCIENCES; biochemical pathways; bioinformatics; Biological Products - chemistry; Biological Products - metabolism; Biological Products - pharmacology; biosynthesis; Biosynthetic Pathways - genetics; chemical reactions; chemical structure; Letter; Molecular Structure; Multigene Family; mutants; natural products; organic compounds; quinone epoxide; Quinones - chemistry; Quinones - metabolism; Quinones - pharmacology; Salicylates - chemistry; Salicylates - metabolism; terreic acid

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic...