Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic...

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Published inOrganic letters Vol. 16; no. 20; pp. 5250 - 5253
Main Authors Guo, Chun-Jun, Sun, Wei-Wen, Bruno, Kenneth S, Wang, Clay C. C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.10.2014
Subjects
Aspergillus - chemistry
Aspergillus - genetics
Aspergillus terreus
BASIC BIOLOGICAL SCIENCES
biochemical pathways
bioinformatics
Biological Products - chemistry
Biological Products - metabolism
Biological Products - pharmacology
biosynthesis
Biosynthetic Pathways - genetics
chemical reactions
chemical structure
Letter
Molecular Structure
Multigene Family
mutants
natural products
organic compounds
quinone epoxide
Quinones - chemistry
Quinones - metabolism
Quinones - pharmacology
Salicylates - chemistry
Salicylates - metabolism
terreic acid
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Summary:Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
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content type line 23
AC05-76RL01830; PO1GM084077; 1136903
PNNL-SA-102991
USDOE Office of Energy Efficiency and Renewable Energy (EERE), Sustainable Transportation Office. Bioenergy Technologies Office
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/ol502242a