Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic...

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Published inOrganic letters Vol. 16; no. 20; pp. 5250 - 5253
Main Authors Guo, Chun-Jun, Sun, Wei-Wen, Bruno, Kenneth S, Wang, Clay C. C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.10.2014
Subjects
Aspergillus - chemistry
Aspergillus - genetics
Aspergillus terreus
BASIC BIOLOGICAL SCIENCES
biochemical pathways
bioinformatics
Biological Products - chemistry
Biological Products - metabolism
Biological Products - pharmacology
biosynthesis
Biosynthetic Pathways - genetics
chemical reactions
chemical structure
Letter
Molecular Structure
Multigene Family
mutants
natural products
organic compounds
quinone epoxide
Quinones - chemistry
Quinones - metabolism
Quinones - pharmacology
Salicylates - chemistry
Salicylates - metabolism
terreic acid
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Abstract Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
AbstractList Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, in combined with bioinformatic analyses, allowed us to propose a biosynthetic pathway for terreic acid. Lastly, defining the pathway and the genes involved will facilitate the engineering of this molecule with interesting antimicrobial and antitumor bioactivities.
Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
Author Wang, Clay C. C
Bruno, Kenneth S
Sun, Wei-Wen
Guo, Chun-Jun
AuthorAffiliation Department of Chemistry, Dornsife College of Letters, Arts, and Sciences
Chemical and Biological Process Development Group, Energy and Environment Directorate
University of Southern California
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy
Pacific Northwest National Laboratory
AuthorAffiliation_xml – name: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy
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Snippet Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the...
Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the...
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SubjectTerms Aspergillus - chemistry
Aspergillus - genetics
Aspergillus terreus
BASIC BIOLOGICAL SCIENCES
biochemical pathways
bioinformatics
Biological Products - chemistry
Biological Products - metabolism
Biological Products - pharmacology
biosynthesis
Biosynthetic Pathways - genetics
chemical reactions
chemical structure
Letter
Molecular Structure
Multigene Family
mutants
natural products
organic compounds
quinone epoxide
Quinones - chemistry
Quinones - metabolism
Quinones - pharmacology
Salicylates - chemistry
Salicylates - metabolism
terreic acid
Title Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus
URI http://dx.doi.org/10.1021/ol502242a
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