Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pat...

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Published inOrganic letters Vol. 14; no. 22; pp. 5684 - 5687
Main Authors Guo, Chun-Jun, Knox, Benjamin P, Chiang, Yi-Ming, Lo, Hsien-Chun, Sanchez, James F, Lee, Kuan-Han, Oakley, Berl R, Bruno, Kenneth S, Wang, Clay C. C
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.11.2012
Amer Chemical Soc
Subjects
Aspergillus nidulans - chemistry
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
Chemistry
Chemistry, Organic
Molecular Structure
Physical Sciences
Science & Technology
Terpenes - chemistry
ASPERGILLUS-TERREUS
3,5-DIMETHYLORSELLINATE
AUSTIN
METABOLITE
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Summary:Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
Bibliography:NIH RePORTER
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol302682z