Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum

• Published in: Antimicrobial Agents and Chemotherapy Vol. 40; no. 1; pp. 173 - 178
• Main Authors: GAVALDA, J, CARDONA, P. J, ALMIRANTE, B, CAPDEVILA, J. A, LAGUARDA, M, POU, L, CRESPO, E, PIGRAU, C, PAHISSA, A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.01.1996
• Subjects: Ampicillin; Ampicillin - blood; Ampicillin - pharmacokinetics; Ampicillin - therapeutic use; Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Comparative Study; Computer Simulation; Culture Media; Drug Administration Schedule; Drug Therapy, Combination; Drug Therapy, Combination - pharmacokinetics; Drug Therapy, Combination - therapeutic use; Endocarditis, Bacterial; Endocarditis, Bacterial - drug therapy; Endocarditis, Bacterial - microbiology; Enterococcus faecalis; Enterococcus faecalis - drug effects; Gentamicins; Gentamicins - pharmacokinetics; Gentamicins - therapeutic use; Gram-Positive Bacterial Infections; Gram-Positive Bacterial Infections - drug therapy; Gram-Positive Bacterial Infections - microbiology; Humans; Infusion Pumps; Medical sciences; Models, Biological; Pharmacology. Drug treatments; Rabbits; Research Support, Non-U.S. Gov't; Serum Bactericidal Test; Enterococcus faecalis; Animal model; Drug combination; Rabbit; Cardiovascular disease; Administration schedule; Lagomorpha; In vitro; Penicillin derivatives; Streptococcaceae; In vivo; Vertebrata; Antibiotic; Chemotherapy; Mammalia; Treatment; Heart disease; Aminoglycoside; Endocardial disease; Endocarditis; Bacteria; Micrococcales; Antibacterial agent; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.40.1.173

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