Relationship Between Corpus Callosum Abnormalities and Schneiderian First-Rank Symptoms in Antipsychotic-Naïve Schizophrenia Patients

• Published in: The journal of neuropsychiatry and clinical neurosciences Vol. 23; no. 2; pp. 155 - 162
• Main Authors: Rao, Naren P, Venkatasubramanian, Ganesan, Arasappa, Rashmi, Gangadhar, Bangalore N
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Publishing, Inc 01.04.2011; American Psychiatric Publishing
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Corpus Callosum - pathology; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Neuropsychological Tests; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - pathology; Surveys and Questionnaires; Psychosis; Human; Central nervous system; Schizophrenia; First-rank symptom; Corpus callosum; Encephalon
• ISSN: 0895-0172; 1545-7222
• DOI: 10.1176/jnp.23.2.jnp155

The corpus callosum (CC), has been hypothesized to be implicated in the pathogenesis of schizophrenia; however, the findings from magnetic resonance imaging studies are conflicting. Moreover, the relationship between first-rank-symptoms (FRS) and CC abnormalities in schizophrenia is yet to be examined. The authors examined CC morphometry, based on Witelson's method, in antipsychotic-naïve-schizophrenia patients in comparison with matched healthy-control subjects. Patients had significantly smaller CC, splenium, and isthmus areas than control subjects. A novel finding of the study is that only those without FRS differed from control subjects, but not those with FRS. Study findings support a neuro-developmental hypothesis and possible connectivity abnormalities in symptom-genesis.