A Life's Journey Through Insect Metamorphosis

• Published in: Annual review of entomology Vol. 65; no. 1; pp. 1 - 16
• Main Author: Riddiford, Lynn M
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 07.01.2020
• Subjects: Animals; autobiography; Biological Evolution; Drosophila - physiology; Drosophila melanogaster; ecdysone; Endocrinology - history; Entomology - history; History, 20th Century; History, 21st Century; juvenile hormone; Juvenile Hormones - metabolism; Larva - physiology; Manduca - physiology; Manduca sexta; Metamorphosis, Biological; Riddiford; Smell; Universities - history; Manduca sexta; juvenile hormone; autobiography; ecdysone; Drosophila melanogaster
• ISSN: 0066-4170; 1545-4487
• DOI: 10.1146/annurev-ento-011019-025103

This autobiographical article describes the research career of Lynn M. Riddiford from its early beginnings in a summer program for high school students at Jackson Laboratory to the present "retirement" at the Friday Harbor Laboratories. The emphasis is on her forays into many areas of insect endocrinology, supported by her graduate students and postdoctoral associates. The main theme is the hormonal regulation of metamorphosis, especially the roles of juvenile hormone (JH). The article describes the work of her laboratory first in the elucidation of the endocrinology of the tobacco hornworm, Manduca sexta , and later in the molecular aspects of the regulation of cuticular and pigment proteins and of the ecdysone-induced transcription factor cascade during molting and metamorphosis. Later studies utilized Drosophila melanogaster to answer further questions about the actions of JH.