Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions

Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficultespecially for materials below 1000 nm. In...

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Published inACS applied bio materials Vol. 2; no. 10; pp. 4667 - 4674
Main Authors Lemaster, Jeanne E, Jeevarathinam, Ananthakrishnan Soundaram, Kumar, Ajay, Chandrasekar, Bhargavi, Chen, Fang, Jokerst, Jesse V
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 21.10.2019
Subjects
synthesis
polydopamine
facile preparation
synthetic melanin nanoparticles
melanin
UV irradiation
mechanism
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Summary:Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficultespecially for materials below 1000 nm. In this paper we describe the synthesis of ultrasmall synthetic nanoparticles with size of 9.4–31.4 nm in weakly acidic and neutral conditions via UV-irradiation. Size control of these particles was possible by varying the pH from 6.4–10.0. We then used UV–vis, FTIR, and nuclear magnetic resonance to investigate the mechanism of UV-induced polymerization. The data show that reactive oxygen species from UV irradiation oxidizes intermediates of the reaction and accelerates the formation of these synthetic melanin structures.
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Author Contributions
The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.9b00747