DNA-Functionalized Supramolecular Polymers: Dynamic Multicomponent Assemblies with Emergent Properties

Recent years have witnessed an increasing interest in hybrid molecular systems in which the programmability of DNA hybridization is used to introduce enhanced molecular control in synthetic systems. The first examples of DNA-functionalized supramolecular polymers have been reported only recently, bu...

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Bibliographic Details
Published inBioconjugate chemistry Vol. 30; no. 7; pp. 1905 - 1914
Main Authors Wijnands, Sjors P.W, Meijer, E. W, Merkx, Maarten
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.07.2019
Subjects
Animals
Biocompatible Materials - chemistry
Deoxyribonucleic acid
DNA
DNA - chemistry
Humans
Hybrid systems
Hybridization
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
Nucleic Acid Hybridization
Peptides - chemistry
Polymers
Polymers - chemistry
Properties (attributes)
Structure-function relationships
Supramolecular polymers
Surface-Active Agents - chemistry
Topical Review
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Summary:Recent years have witnessed an increasing interest in hybrid molecular systems in which the programmability of DNA hybridization is used to introduce enhanced molecular control in synthetic systems. The first examples of DNA-functionalized supramolecular polymers have been reported only recently, but have already revealed structural and functional properties that are not easily obtained in either synthetic supramolecular polymers or DNA-only based systems. In this Topical Review, we provide an overview of the various forms of additional control offered by DNA hybridization for different types of supramolecular polymers and discuss how orthogonal supramolecular interactions in these hybrid systems can give rise to emergent structural and functional properties.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.9b00095