Multi-omics analyses of the gut microbiota and metabolites in children with metabolic dysfunction-associated steatotic liver disease

• Published in: mSystems Vol. 10; no. 4; p. e0114824
• Main Authors: Du, Landuoduo, Zhang, Kaichuang, Liang, Lili, Yang, Yi, Lu, Deyun, Zhou, Yongchang, Ren, Tianyi, Fan, Jiangao, Zhang, Huiwen, Wang, Ying, Jiang, Lu
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.04.2025
• Subjects: Adolescent; Alanine transaminase; biomarker; Biomarkers - metabolism; Body mass index; Case-Control Studies; Child; Children; Children & youth; Clinical Microbiology; Deoxycholic acid; DNA sequencing; Fatty Liver - metabolism; Fatty Liver - microbiology; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome; Gut microbiota; Homogenization; Humans; Intestinal microflora; Liver diseases; Male; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Microbiota; Multiomics; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - microbiology; Obesity; Patients; pediatric; Pediatrics; Research Article; Ribosomal DNA; Ruminococcus; Ruminococcus torques; Software; steatosis; Taxonomy; Variance analysis; United States > US; China; Shanghai China; deoxycholic acid; biomarker; steatosis; Ruminococcus torques; pediatric
• ISSN: 2379-5077; 2379-5077
• DOI: 10.1128/msystems.01148-24

This study investigated alterations in the gut microbiota signature and microbial metabolites in children with metabolic dysfunction-associated steatotic liver disease (MASLD). We found that an increased abundance of Ruminococcus torques was associated with increased levels of deoxycholic acid and the progression of MASLD, suggesting that R. torques may serve as a novel clinical target in pediatric MASLD.