Regioselective, Photocatalytic α‑Functionalization of Amines

Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with min...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 142; no. 28; pp. 11972 - 11977
Main Authors Leng, Lingying, Fu, Yue, Liu, Peng, Ready, Joseph M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.07.2020
Amer Chemical Soc
Subjects
Amines - chemical synthesis
Amines - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Molecular Structure
Photochemical Processes
Physical Sciences
Science & Technology
Stereoisomerism
LIGHT PHOTOREDOX CATALYSIS
RADICALS
GENERATION
NICKEL
BONDS
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Summary:Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.0c03758