Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal

The RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antima...

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Published inAntimicrobial agents and chemotherapy Vol. 60; no. 8; pp. 5010 - 5013
Main Authors Gendrot, Mathieu, Fall, Bécaye, Madamet, Marylin, Fall, Mansour, Wade, Khalifa Ababacar, Amalvict, Rémy, Nakoulima, Aminata, Benoit, Nicolas, Diawara, Silman, Diémé, Yaya, Diatta, Bakary, Wade, Boubacar, Pradines, Bruno
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.08.2016
Subjects
Antimalarials
Antimalarials - pharmacology
Artemisinins - pharmacology
Chloroquine - analogs & derivatives
Chloroquine - pharmacology
Doxycycline - pharmacology
Ethanolamines - pharmacology
Fluorenes - pharmacology
Human health and pathology
Infectious diseases
Life Sciences
Mechanisms of Resistance
Mefloquine - pharmacology
Naphthyridines - pharmacology
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Polymorphism, Genetic
Polymorphism, Genetic - genetics
Quinine - pharmacology
Quinolines - pharmacology
Senegal
Ubiquitin-Protein Ligases
Ubiquitin-Protein Ligases - genetics
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Summary:The RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antimalarial drugs. However, some mutated isolates (D113N) present a trend of reduced susceptibility to piperaquine (P = 0.0938). To evaluate the association of D113N polymorphism with susceptibility to antimalarials, more isolates are necessary.
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PMCID: PMC4958203
Citation Gendrot M, Fall B, Madamet M, Fall M, Wade KA, Amalvict R, Nakoulima A, Benoit N, Diawara S, Diémé Y, Diatta B, Wade B, Pradines B. 2016. Absence of association between polymorphisms in the RING E3 ubiquitin protein ligase gene and ex vivo susceptibility to conventional antimalarial drugs in Plasmodium falciparum isolates from Dakar, Senegal. Antimicrob Agents Chemother 60:5010–5013. doi:10.1128/AAC.03105-15.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.03105-15