A stress and coping model of medication adherence and viral load in HIV-positive men and women on highly active antiretroviral therapy (HAART)

The authors tested a structural model that incorporated age, time since diagnosis, social support, coping, and negative mood as predictors of medication adherence and HIV viral load on 188 men and 134 women on highly active antiretroviral therapy (HAART). The authors used psychosocial latent factors...

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Bibliographic Details
Published inHealth psychology Vol. 24; no. 4; p. 385
Main Authors Weaver, Kathryn E, Llabre, María M, Durán, Ron E, Antoni, Michael H, Ironson, Gail, Penedo, Frank J, Schneiderman, Neil
Format Journal Article
LanguageEnglish
Published United States 01.07.2005
Subjects
Adaptation, Psychological
Adolescent
Adult
Aged
Antiretroviral Therapy, Highly Active
Female
Florida
HIV Seropositivity - drug therapy
HIV Seropositivity - psychology
Humans
Longitudinal Studies
Male
Middle Aged
Models, Theoretical
Patient Compliance
Social Support
Viral Load
Florida
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Summary:The authors tested a structural model that incorporated age, time since diagnosis, social support, coping, and negative mood as predictors of medication adherence and HIV viral load on 188 men and 134 women on highly active antiretroviral therapy (HAART). The authors used psychosocial latent factors formed from baseline measures to predict latent factors of adherence, as assessed by electronic monitoring and self-report, and viral load defined by indicators assessed over a 15-month period. Results from the model indicate that greater negative mood and lower social support are related to greater use of avoidance-oriented coping strategies. Use of these coping strategies by patients on HAART is related to poorer medication adherence and, subsequently, higher viral load. This model advances researchers' understanding of the contribution of psychosocial variables in predicting treatment adherence and disease progression in HIV-positive men and women.
ISSN:0278-6133
DOI:10.1037/0278-6133.24.4.385