Multiple recombination events between endogenous retroviral elements and feline leukemia virus

Feline leukemia virus subgroup A (FeLV-A) is primarily transmitted among cats. During viral transmission, genetic changes in the viral genome lead to the emergence of novel FeLV subgroups or variants with altered virulence. We isolated three FeLV subgroups (A, B, and D) and XR-FeLV from two cats and...

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Published inJournal of virology Vol. 98; no. 2; p. e0140023
Main Authors Ngo, Minh Ha, AbuEed, Loai, Kawasaki, Junna, Oishi, Naoki, Pramono, Didik, Kimura, Tohru, Sakurai, Masashi, Watanabe, Kenji, Mizukami, Yoichi, Ochi, Haruyo, Anai, Yukari, Odahara, Yuka, Umehara, Daigo, Kawamura, Maki, Watanabe, Shinya, Miyake, Ariko, Nishigaki, Kazuo
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 20.02.2024
Subjects
Animals
Cats
Endogenous Retroviruses - genetics
Leukemia Virus, Feline - genetics
Leukemia Virus, Feline - physiology
Leukemia, Feline - transmission
Leukemia, Feline - virology
Pathogenesis and Immunity
Recombination, Genetic
Veterinary Microbiology
pathogenesis
genetic recombination
feline leukemia virus
transmission
domestic cats
endogenous retroviruses
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Summary:Feline leukemia virus subgroup A (FeLV-A) is primarily transmitted among cats. During viral transmission, genetic changes in the viral genome lead to the emergence of novel FeLV subgroups or variants with altered virulence. We isolated three FeLV subgroups (A, B, and D) and XR-FeLV from two cats and identified multiple recombination events in feline endogenous retroviruses (ERVs), such as enFeLV, ERV-DC, and FcERV-gamma4, which are present in the cat genome. This study highlights the pathogenic contribution of ERVs in the emergence of FeLV-B, FeLV-D, and XR-FeLV in a feline population.
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Minh Ha Ngo, Loai AbuEed, Junna Kawasaki, Didik Pramono, and Ariko Miyake contributed equally to this article. The order of authors was determined based on the order in which the research was started, spanning 15 years. Another was ordered according to seniority.
The authors declare no conflict of interest.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/jvi.01400-23