Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria

Serving as an adaptive immune system, clustered regularly interspaced short palindromic repeats and their associated proteins (CRISPR-Cas) empower prokaryotes to fend off the intrusion of external genetic materials. Myxobacteria are a collective of swarming Gram-stain-negative predatory bacteria dis...

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Published inmSystems Vol. 9; no. 6; p. e0121023
Main Authors Hu, Wei-feng, Yang, Jiang-yu, Wang, Jing-jing, Yuan, Shu-fei, Yue, Xin-jing, Zhang, Zheng, Zhang, Ya-qi, Meng, Jun-yan, Li, Yue-zhong
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 18.06.2024
Subjects
Bacteriology
Clustered Regularly Interspaced Short Palindromic Repeats - genetics
CRISPR
CRISPR-Cas
CRISPR-Cas Systems - genetics
Datasets
DNA repair
Genes
Genetic engineering
Genome, Bacterial - genetics
Genomes
Gram-negative bacteria
Homology
Immune system
immunity
myxobacteria
Myxococcales - genetics
Myxococcus xanthus
Phages
Phylogeny
Plasmids
Prokaryotes
Proteins
Research Article
Social behavior
Social organization
target tracing
CRISPR-Cas
immunity
Myxococcus xanthus
target tracing
myxobacteria
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Summary:Serving as an adaptive immune system, clustered regularly interspaced short palindromic repeats and their associated proteins (CRISPR-Cas) empower prokaryotes to fend off the intrusion of external genetic materials. Myxobacteria are a collective of swarming Gram-stain-negative predatory bacteria distinguished by intricate multicellular social behavior. An in-depth analysis of their intrinsic CRISPR-Cas systems is beneficial for our understanding of the survival strategies employed by host cells within their environmental niches. Moreover, the experimental findings presented in this study not only suggest the robust immune functions of CRISPR-Cas in myxobacteria but also their potential applications.
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The authors declare no conflict of interest.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.01210-23