Characterizing alterations in the gut microbiota following postpartum weight change

Previous research has reported differences in the gut microbiome associated with varying body compositions. More specifically, within populations of mothers, the focus has been on the impact of gestational weight gain. This is the first study to examine postpartum weight change and its association w...

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Bibliographic Details
Published inmSystems Vol. 8; no. 6; p. e0080823
Main Authors Chalifour, Bridget N, Trifonova, Diana I, Holzhausen, Elizabeth A, Bailey, Maximilian J, Schmidt, Kelsey A, Babaei, Mahsa, Mokhtari, Pari, Goran, Michael I, Alderete, Tanya L
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 21.12.2023
Subjects
Antibiotics
Body weight gain
Body weight loss
Carbohydrates
Community structure
Connectivity
Digestive system
Exercise
Female
Gastrointestinal Microbiome
gut microbiome
Human Microbiome
Humans
Intestinal microflora
Latinas
Microbiomes
Microbiota
Mothers
network analysis
Obesity
Overweight
Postpartum
Postpartum Period
Pregnancy
Relative abundance
Research Article
RNA, Ribosomal, 16S
rRNA 16S
Socioeconomic factors
Statistical analysis
Weight control
Weight Gain
Womens health
postpartum
network analysis
gut microbiome
Latinas
obesity
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Summary:Previous research has reported differences in the gut microbiome associated with varying body compositions. More specifically, within populations of mothers, the focus has been on the impact of gestational weight gain. This is the first study to examine postpartum weight change and its association with changes in the gut microbiome, similarly, it is the first to use a Latina cohort to do so. The results support the idea that weight gain may be an important factor in reducing gut microbiome network connectivity, diversity, and changing abundances of specific microbial taxa, all measures thought to impact host health. These results suggest that weight gain dynamically alters mothers' gut microbial communities in the first 6 months postpartum, with comparatively little change in mothers who lost weight; further research is needed to examine the health consequences of such changes.
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Michael I. Goran receives book royalties. He is a scientific advisor for Yumi.
Bridget N. Chalifour and Diana I. Trifonova contributed equally to this article. Author order was determined alphabetically.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.00808-23